Vitamin D – Deficiency/Symptoms

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Vitamin D deficiency may be characterized by muscle pain, weak bones/fractures, low energy and fatigue, lowered immunity, symptoms of depression and mood swings, and sleep irregularities. Women with renal problems or intestinal concerns (such as IBS or Crohn’s disease) may be vitamin D deficient because they can neither absorb nor adequately convert the nutrient.

See Dr. Holick’s comments below:

Osteomalacia and Vitamin D

Posted by admin on under Osteomalacia, Vitamin D |

Vitamin D deficiency causes a defect in the ability of the body to deposit calcium into the collagen jello-like matrix in the bone.  As a result, the covering on the bone which contains pain sensing nerves is easily deformed resulting in throbbing aching bone pain.  Patients with osteomalacia often complain of achiness in their muscles and bones.  These non-specific aches and pains in the bones and muscles are often misdiagnoses as fibromyalgia or chronic fatigue syndrome.  There have been several studies demonstrating that patients with severe bone and muscle pain and muscle weakness associated with osteomalacia have dramatic improvement in their symptoms when vitamin D deficiency is corrected.  It takes months to years to develop osteomalacia and associated symptoms and it takes three to six months before significant improvement in symptoms results from correcting vitamin D deficiency.  

References:

Holick, M.F.  Vitamin D deficiency:  What a Pain it is.  Mayo Clin. Proc.  2003; 78(12): 1457-1459.

Malabanan AO, Turner AK, Holick MF. Severe generalized bone pain and osteoporosis in a premenopausal black female: effect of vitamin D replacement. J Clin Densitometr . 1998;1:201-204.

and also…

Osteoporosis and Vitamin D

Posted by admin on under Osteoporosis, Vitamin D |

Vitamin D deficiency will cause removal of both the calcium and matrix from the bone, and as a result, will cause osteopenia and can precipitate and exacerbate osteoporosis.  Unlike osteomalacia which causes bone pain, osteoporosis, which is porotic bone, i.e., holes in the bones and loss of bone does not cause bone pain unless there is an acute fracture.  Typically this pain resolves as the fracture heals and can be easily distinguished from osteomalacia.  

References:

Bischoff-Ferrari, HA, Giovannucci, E., Willett, W.C., Dietrich, T., and Dawson-Hughes, B.  Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes.  Am J Clin Nutr  2006; 84:18-28.  

Boonen S, Bischoff-Ferrari A, Cooper C, Lips P, Ljunggren O, Meunier PJ, Reginster JY.  Addressing the musculoskeletal components of fracture risk with calcium and vitamin D:  a review of the evidence.  Calcif Tissue Int  2006; 78(5):257-70.

Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ.  Vitamin D3 and calcium to prevent hip fractures in elderly women.  N Engl J Med 1992; 327(23):1637-1642.

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